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            產品詳情
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            簡單介紹:
            美國哈佛儀器旗下BTX公司自1983年成立以來,以電穿孔儀、電融合儀為主要產品,是第壹家生產高質量電穿孔儀器的生產廠家,開創了許多在電穿孔、電融合、轉染、轉化等方面的新產品和技術,不僅為全球在此領域的研究者提供了BTX專業產品,而 且擁有多至25種的配件,包括:電穿孔、電融合、活體導入配件等等,成為全球唯壹專業的轉基因、電融合、活體轉基因儀及配件的生產廠家。
            詳情介紹:
            Agile Pulse In Vivo系統是疫苗和免役接種研究者的理想選擇。系統根據皮下接種(ID)和肌肉接種(IM)的應用特點分別配置了特別設計的針形矩陣電極,并且對電轉染儀的程序進行了特別優化,帶給您更高的轉染效率。電穿孔技術配合質粒注射技術使用,在基因表達及持續性和產生免役原性上顯示出高達100倍的增長。Pulse Agile技術,首先利用短時間高強度的脈沖使細胞膜產生通透性,再利用低強度脈沖促進DNA導入細胞,配合多針矩陣電極的使用,大大促進了抗原在細胞內的表達。Agile Pulse系統配有豐富多樣的多針矩陣電極選擇,并且內置電阻測量技術,大大促進了皮下和肌肉免役接種技術。

            Agile Pulse In Vivo系統能有效增強免役反應并縮短免役接種程序,從而極大提高您的實驗效率。

             

            Agile Pulse In Vivo系統廣泛應用于:

            皮下DNA疫苗接種

            肌肉DNA疫苗接種

            肌肉DNA疫苗接種

            Drug導入

             

            特點:

            方波

            多重方波

            電阻/電擊脈沖監控

            實驗日志存儲

            無限量自定義程序存貯

            遠程控制

             

            電穿孔應用:

            真核細胞

            活體(活體電極)

            皮下接種(針形矩陣電極)

            肌肉接種(針形矩陣電極)

             

            技術參數:

            用戶界面:觸摸屏

            電壓:50 - 1000 v

            脈沖時間:5 μs - 10 ms

            脈沖間隔時間:20 μs - 1 s

            數據輸出:USB

            產品尺寸(長x x高):12.6 x 7.9 x 15.7 in

            重量:25 lbs

            工作溫度:10° - 40° C

            輸入電壓:100 - 250 VAC

             


            已發表文獻:

            Bongard N, Lapuente D, Windmann S, Dittmer U, Tenbusch M, Bayer, W. Interference of Retroviral Envelope with Vaccine-Induced CD8+ T Cell Responses is Relieved by Co-Administration of Cytokine-Encoding VectorsRetrovirology. 2017;14: 28.

             

            Eyquem J, et al. Targeting a CAR to the TRAC Locus with CRISPR/Cas9 Enhances Tumour Rejection. Nature. 2017;543: 113-117.

             

            Juillerat A, et al. An Oxygen Sensitive Self-Decision Making Engineered CAR T-CellSci Rep. 2017 Jan 20;7: 39833.

             

            Denies S, et al. Evaluation of a Xenogeneic Vascular Endothelial Growth Factor-2 vaccine in Two Preclinical Metastatic Tumor Models in MiceCancer Immunol Immunother. 2017 Dec;66(12): 1545-1555.

             

            Juillerat A, et al. Design of Chimeric Antigen Receptors with Integrated Controllable Transient FunctionsSci Rep. 2016 Jan 11;6: 18950.

             

            Peterson CW, et al. Long-Term Multi-Lineage Engraftment of Genome-Edited Hematopoietic Stem Cells after Autologous Transplantation in Nonhuman PrimatesBlood. 2016 May 19;127(20): 2416-2426.

             

            Hawksworth DJ, Ziemann R, Manoj S. Enhanced Immune Response Following DNA Immunization Through In Vivo ElectroporationMonoclon Antib IImmunodiagn Immunother. 2016 Jul 27;35(5): 239-244.

             

            Juillerat A, et al. Design of chimeric antigen receptors with integrated controllable transient functionsSci Rep. 2016 Jan 11;6: 18950.

             

            Christopher W, et al, Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primatesBlood. 2016;127: 2416-2426.

             

            Wang L, et al. Evaluation of Candidate Vaccine Approaches for MERS-CoVNat Comm. 2015 Jul28;6:7 712.

             

            Davtyan H, et al. BTX AgilePulse(TM) System is an Effective Electroporation Device for Intramuscular and Intradermal Delivery of DNA Vaccine. Curr Gene Ther. 2014;14(3): 190-199.

             

            Daftarian MP, Vosoughi A, Lemmon V. Gene-Based Vaccination and Screening Methods to Develop Monoclonal Antibodies. Methods Mol Biol. 2014;1121: 337-346.

             

            Johansson DX, Ljungberg K, Kakoulidou M, Liljestrom P. Intradermal Electroporation of Naked Replicon RNA Elicits Strong Immune ResponsesPLoS One, 2012 Jan 4;7(1): e29732.

             

            Lladser A, Ljungberg K, Tufvesson H, Tazzari M, Roos A, Quest FG, Kiessling R. Intradermal electroporation with a survivin DNA vaccine induces CTLs against a self-epitope, suppresses angiogenesis and confers long-term protection against mouse melanomaCancer Immunol Immunother. 2010 Jan;59(1): 81-92.

             

            Lundberg K, Roos A-K, Pavlenko M, Wehrum D, Pisa P. A modified epitope identified for generation and monitoring of PSA-specific T cells in patients on early phases of PSA-based immunotherapeutic protocolsVaccine. 2009 Mar 4;27(10): 1557-65.

             

            Br?ve A, Halleng?rd D, Gudmundsdotter L, Stout R, Walters R, Wahren B, Hallermalm K. Late administration of plasmid DNA by intradermal electroporation efficiently boosts DNA-primed T and B cell responses to carcinoembryonic antigenVaccine. 2009 Jun 8;27(28): 3692-6.

             

            Roos, A-K, Eriksson, F, Walters, D, Pisa, P, King, A. Optimization of skin electroporation in mice to increase tolerability of DNA vaccine delivery to patientsMolecular Therapy. 2009 Sep;17(9): 1637-42.




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